2型糖尿病视网膜病变相关因素分析

Analysis on the related factors of retinopathy in patients with type 2 diabetes mellitus

目的分析影响2型糖尿病视网膜病变(DR)发生发展的相关因素。方法对324例2型糖尿病患者的眼底、血压、糖化血红蛋白(HbA1c)、血糖、肌酐、尿酸(UA)及24h尿白蛋白排泄率(UAER)等进行回顾性分析。结果2型糖尿病DR总患病率为44.4%(144/324),其中单纯性(BDR)占79.8%(115/144),增殖性(PDR)占20.1%(29/144);DR患者的病程、UA、Cr、BUN、UAER和收缩压均显著高于NDR患者(P<0.01);PDR患者的病程显著长于NDR(P<0.001),PDR患者PBG、收缩压、舒张压显著高于BDR患者(P<0.05)。Logistic多元回归分析显示,病程、年龄及UAER是DR发病的独立危险因素。结论DR与糖尿病病程、UAER及血糖升高及血压升高有关,病程、餐后血糖及UAER是DR发生的重要危险因素。

Objective To analyses the related factors of the development of diabetic retinopathy（DR） in type 2 diabetes meUitus. Methods 324 cases with type 2 diabetes mellitus were analysed retrospectively, the diabetic retinopathy （DR） ,blood pressure and the levels of glycosylated haemoglobin （HbA1c） ,fasting and postprandial blood sugar,serum creatinine （Cr）, uric acid （UA） and urinary album in excretion rate （UAER） were examined. Results The morbidity rate of background DR in type 2 diabetes meUitus was 44.4% （144/324）, in which the morbidity rate of BDR 79.8% （ 115/144）, and the morbidity rate of PDR was 20.1% （29/144） ; course of the diabetes, UAER, UA, Cr, BUN and systolic pressure in the DR patients were much higher than in the normal DR;postprandial blood sugar, systolic pressure and diastolic pressure in the PDR were much higher than those in patients with BDRo The independent risk factors of DR were duration of the diseases, age and UAER. Conclusions The duration of the disease, postprandial blood sugar hypertension and UAER are the important risk factors of development and progression of diabetic retinopathy.