hPOT1在端粒长度维持机制中的研究进展被引量：1

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摘要端粒是真核生物染色体末端的重要结构复合物,对维持染色体稳定性起着重要作用。端粒长度的调控非常复杂。端粒长度的维持,一方面依赖端粒酶,另一方面则依赖端粒结合蛋白。端粒保护蛋白(POT1)为端粒单链结合蛋白,近年来对hPOT1结构、功能及其在肿瘤中的表达研究表明,其与端粒长度的维持密切相关。

作者杜小玲孙宏声张维铭

机构地区天津医科大学实验中心分子生物学实验室

出处《国外医学（临床生物化学与检验学分册）》 2005年第8期520-522,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine

关键词 hPOTl 端粒长度维持机制端粒保护蛋白肿瘤

参考文献17

1Miura T, Mattson MP, Rao MS. Cellular lifespan and senescence signaling in embryonic stem cells. Aging Cell,2004, 3(6):333-343.
2Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer. Science, 2002, 297(5581): 565-569.
3Smogorzewska A, de-Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem, 2004, 73: 177-208.
4Baumann P, Podell E, Cech TR. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol, 2002, 22(22): 8079-8087.
5Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science, 2001, 292(5519): 1171-1175.
6Loayza D, De-Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature, 2003, 423(6943): 1013-1018.
7Liu D, Safari A, O′Connor MS, et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol, 2004, 6(7): 673-680.
8Mitton-Fry RM, Anderson EM, Hughes TR, et al. Conserved structure for single-stranded telomeric DNA recognition. Science, 2002, 296(5565): 145-147.
9Colgin LM, Baran K, Baumann P, et al. Human POT1 facilitates telomere elongation by telomerase. Curr Biol, 2003, 13(11): 942-946.
10Blackburn EH. Switching and signaling at the telomere. Cell, 2001, 106(6): 661-673.

1Blasco MA, Gasser SM, Lingner J. Telomeres and telomerase[J].Genes Dev, 1999,13:2353
2Baumann P, Cech TR. Pot1,the putative telomere end-binding protein in fission yeast and humans[J]. Science,2001,292(5519):1171
3Stewart SA, Porath I, Carey V J, et al. Erosion of the telomeric single-strand overhang at replicative senescence[J]. Nature Genetics, 2003,33:492
4Colgin LM, Baran K, Baumann P, et al. Human POT1 facilitates telomere elongation by telomerase[J]. Curr Biol, 2003,13(11):942
5De Lange T. Pot1 as a terminal transducer of TRF1 telomere length control[J]. Nature, 2003,424(6943): 1013

1帖君,房殿春,宁晓燕,罗元辉.人端粒保护蛋白在胃癌中的异常表达及其临床意义[J].胃肠病学和肝病学杂志,2006,15(1):12-14. 被引量：2
2安红梅,胡兵,史云峰,许丽雯,胡云皓,顾耘.补肾填精复方含药血清对WI38细胞衰老的影响[J].陕西中医学院学报,2007,30(1):40-42. 被引量：12
3张之南,沈悌.血液病诊断及疗效标准[M].3版,北京,北京科学出版社,2008:232-235.
4Brummendorf TH,Macie Jewski JP,Mak J,et al. Telomere length in leukocyte subpopulations of patients with aplastic anemia[J]. Blood,2001,97(4):895-900.
5Young NS,Bacigalupo A,Marsh JC. Aplastic anemia: pathophysiology and treatment[J]. Biol Blood Marrow Transplant,2010,16(1):S119-125.
6Baumann P,Cech TR. Pot1,the putative telomere end-binding protein in fission yeast and humans[J]. Science,2001,292(5519):1171-1175.
7Young NS. Telomere biology and telomere diseases:implications for practice and research[J]. Hematology Am Soc Hematol Educ Program,2010(1):30-35.
8Scheinberg P,Cooper JN,Sloand EM,et al. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse,malignant transformation,and survival in severe aplastic anemia[J]. JAMA,2010,304:1358-1364.
9De Lange T. T-loops and the origin of telomeres[J]. Nat Rev Mol Cell Biol,2004,5(4):323.
10Colgin LM,Baran K,Baumann P,et al. Human POT1 facilitates telomere elongation by telomerase[J]. Curr Biol,2003,13:942- 946.

1吴平,赵素萍,章华,蒋卫红.TRF1及hPOT1 mRNA在鼻咽癌组织中的表达及临床意义[J].中国现代医学杂志,2011,21(18):2136-2138. 被引量：1
2袁芳,蒋代富,李春鸣.胃癌组织中hPOT1和p53表达及其临床意义[J].山东医药,2011,51(7):4-6. 被引量：1
3青玉凤,吴凤霞,周京国,袁国华.端粒保护蛋白在端粒形成和功能维护中的作用[J].国际遗传学杂志,2008,31(6):450-452. 被引量：4
4宁晓燕,房殿春,郭丽萍,李宜成,帖君,杨仕明,汪荣泉,彭贵勇,陈文生.hPOT1 RNA干扰对人胃癌BGC823细胞突变型p53表达的影响[J].胃肠病学和肝病学杂志,2008,17(5):390-393.
5朱少金（综述）,杨小龙（审校）.人端粒保护蛋白（hPOT）的研究进展[J].现代保健（医学创新研究）,2007(07X):25-26.
6器官发育过程中祖细胞特性维持机制[J].生物医学工程与临床,2010,14(2):126-126.
7谢谦,黄洪章.端粒维持机制及肿瘤治疗新策略[J].肿瘤学杂志,2004,10(2):114-116.
8孙瑞清,吴建农,殷瑞根,成静.食管鳞癌组织中hPOT1、hTERT及p53的表达[J].江苏医药,2008,34(9):865-866. 被引量：2
9张艳波,王军.端粒、端粒保护蛋白与动脉粥样硬化的研究进展[J].国际检验医学杂志,2011,32(10):1078-1081. 被引量：4
10付强,朱理玮,王鹏志.内源性端粒酶抑制基因在大肠癌中的表达及临床研究[J].中华普通外科杂志,2004,19(3):157-159. 被引量：3

2005年第8期

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