同型半胱氨酸与急性冠状动脉综合征相关性研究

Study on relation between plasma level of homocysteine and acute coronary syndrome

目的:探讨血浆同型半胱氨酸与急性冠状动脉综合征(ACS)发作期和自身缓解期的相关性。方法:对64例ACS患者的发作期和自身缓解期及64例对照组分别测定血浆同型半胱氨酸浓度并进行比较,同时测定C-反应蛋白对照观察。结果:ACS发作期血浆同型半胱氨酸水平[(26.72±3.2)μmol/L]显著高于对照组[(8.94±2.1)μmol/L]和自身缓解期[(17.88±2.8)μmol/L],均P<0.01。血浆C-反应蛋白在ACS发作期[(14.54±3.1)mg/L]与对照组[(4.36±1.8)mg/L]比较差异有统计学意义(P<0.01)。与自身缓解期[(13.72±5.3)mg/L]比较,则(P>0.05)。结论:ACS患者发作期血浆同型半胱氨酸水平与ACS的发生有关,是动脉粥样硬化斑块不稳定的标志;C-反应蛋白对动脉粥样硬化斑块不稳定性的预测比同型半胱氨酸差。

Objective：To study the relation between plasma homocysteine（Hcy） and acute coronary syndrome （ACS）. Method： Sixty-four ACS patients were enrolled as ACS group. After effective therapy. these 64 patients were as stable coronary heart disease（CHD） group,and 64 normals were as control group. The plasma levels of Hcy and C reactive protein（CRP） were measured in all subjects. Result： ①Hcy level in ACS group was significantly higher than that in control group. ②Hcy level in ACS group was significantly higher than that in stable CHD group. ③CRP level in ACS group was significantly higher than that in control group. ④ Hcy level in ACS group was slightly higher than that in control group,but no significant difference. Conclusion ; Elevated plasma Hcy level is associated with genesis of ACS. Plasma Hcy level is more sensitive than CRP in prediction on unstability of atheroselerosis.