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急性心肌梗死患者氧化低密度脂蛋白抗体测定的临床意义 被引量：1

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摘要 目的:探讨急性心肌梗死(AMI)患者血清氧化低密度脂蛋白抗体(anti-ox-LDL)的变化及临床意义。方法:68例AMI患者入院时根据临床情况分为静脉溶栓治疗组(Ⅰ亚组,46例)及非溶栓组(Ⅱ亚组,无溶栓适应证或存在禁忌证者22例),同时测定所有患者入院即刻及1个月后血清血脂及anti-ox-LDL水平,各组间进行比较并与对照组比较。结果:①AMI患者入院时血清anti-ox-LDL较对照组明显增高(P<0.01),1个月后显著降低(P<0.001)达对照组水平;②Ⅰ亚组、Ⅱ亚组患者入院时anti-ox-LDL差异无统计学意义;③Ⅰ亚组患者溶栓成功组(26例)与未成功组(20例)入院时anti-ox-LDL差异无统计学意义;④Ⅱ亚组患者急诊冠状动脉造影梗死相关动脉(IRA)末开通者(13例)入院时血清anti-ox-LDL明显高于IRA开通者(9例)。结论:anti-ox-LDL升高与冠状动脉硬化斑块的不稳定性有关,可能是AMI发作的一个危险因素,自发性血管再通可能与血清anti-ox-LDL降低有关,而溶栓所致血管再通则与此无关。
作者 张清潭 王爱芹 李宗清 石斗飞
机构地区 滨州医学院附院保健科老年病房 滨州医学院附院口腔科 滨州医学院附院心内科
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2005年第8期494-495,共2页 Journal of Clinical Cardiology
关键词 心肌梗死 抗体 氧化低密度脂蛋白
分类号 R542.2 [医药卫生—心血管疾病]
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临床心血管病杂志
2005年 第8期

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