摘要
对苯二甲酰亮氨酸为氨基酸系表面活性剂中的一类,是由对苯二甲酰氯与亮氨酸通过非均相法合成得到.最佳反应条件为:对苯二甲酰氯与亮氨酸的物质的量比为1∶2.4,对苯二甲酰氯以2~4滴/min的速度缓慢滴入亮氨酸溶液中,反应过程中保持pH 8~9之间,反应温度控制在10~15℃.反应2h后,用浓盐酸调节pH 3~4,使钠盐转化为对苯二甲酰亮氨酸,减压抽滤得粗品.经纯化的产品收率为76.0%.
p-Phthaloyl amino acid is a sort of surface-active agent.Taking p-phthalyl alcohol and leucine as raw material, pphthaloyl leucine was obtained by nonhomogeneous reaction. The optimum conditions for the reaction were:molar ratio of the p-phthalyl alcohol and leucine was 1:2.4,the p-phthalyl alcohol was slowly added into leucine solution, the pH of the solution was kept within 8 - 9 during the reaction, the reaction temperature was controlled at 10- 15℃ .After 2 hours,the pH of the solution was adjusted to 3 - 4 by hydrochloric acid in order to transformed the sodium salt to the acid. The precipitate was collected by filtration under reduced pressure. The yield was 76 % .
出处
《化学试剂》
CAS
CSCD
北大核心
2005年第8期489-490,共2页
Chemical Reagents
基金
国家自然科学基金(29875018)
甘肃省自然科学基金(ZS991-A25-008-Z)
甘肃省高分子材料重点实验室重点项目。