硫普罗宁注射液治疗抗结核药物性肝损害的临床疗效观察

Clinical Observation of Tiopronin on Treatin g Liver Injury Caused by Anti-tuberculosis Drug

目的观察硫普罗宁注射液对抗结核药物所致肝损害的治疗作用。方法将90例因抗结核药物引起肝损害的结核病患者随机分为两组,治疗组58例,给予硫普罗宁注射液治疗,每次600mg,1次/d,对照组32例,不用硫普罗宁注射液治疗,停用抗结核药物。两组所采用的基础治疗相同,疗程均为30d。结果治疗组治疗后血清ALT,AST,TBL下降非常明显,与治疗前相比有显著性差异(P<0.01),两组综合疗效比较,治疗组总有效率明显优于对照组。结论硫普罗宁注射液对抗结核药物所致的肝损害有明显的保护作用。

Objective To observe the effect of Tiopronin on treating liver injury caused by anti tuberculosis （TB） drug. Methods Treatment group （58 cases） was given 600 mg of tiopronin injection daily for 30 days in addition to anti TB drug. Control group was not given Tiopronin and stopped using anti TB drug. The basic therapies of both the groups were the same. Results Comparisons of liver function between the two groups and between before and after treatment were as following. The plasma ALT, AST, TBIL of treatment group decreased obviously, when compared with that before treatment （P 〈 0.01 ）. The therapeutic effect of treatment group was better than that of control group. Condttsion Tiopronin has obvious effect on liver injury caused by anti TB drug.