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辛伐他汀联合非诺贝特治疗混合性高脂血症42例疗效观察 被引量:3

Observation of Simvastatin Plus Fenofibrate for the Treatment of 42 Patients with Mixed Hyperlipemia
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摘要 目的探讨辛伐他汀联合非诺贝特治疗混合性高脂血症的价值。方法将126例混合性高脂血症患者分为三组,每组42例。辛伐他汀组每晚口服10mg辛伐他汀,非诺贝特组每天早晨口服200mg非诺贝特,联合治疗组同时服用辛伐他汀与非诺贝诺特,用法用量与单治疗组相同。结果治疗4个月后各组参数指标均有改善,但联合组的TG,TC,LDL-C降幅明显大于其他两组(P<0·01或0·05);HDL-C升高也明显优于其他两组(P<0·05)。结论联合应用辛伐他汀与非诺贝特能有效降低TG,TC,LDL-C;升高HDL-C。 Objective To discuss the value of simvastatin plus fenofibrate for the treatment of mixed hyperlipemia. Methods All the 126 patients with mixed hyperlipemia were divided into three groups (42 ones per group). Simvastatin group took oral simvastatin at a dose of 10mg every evening, fenofibrate group took oral fenofibrate 200rag every morning, and combined group took simvastatin plus fenofibrate at the same doses as the above. Results All the indexes of the three groups improved after four monthsg treatment, but TG, TC and LDL-C declined and HDL-C rose more significantly in combined group than in the other two groups (P 〈 0.01 or P 〈 0.05 ). Conclusion It is indicated that simvastatin plus fenofibrate can not only effectively lower TG,TC and LDL-C,but raised HDL-C as well.
机构地区 解放军
出处 《临床军医杂志》 CAS 2005年第4期431-433,共3页 Clinical Journal of Medical Officers
关键词 高脂血症 辛伐他汀 非诺贝特 hyperlipemia simvastatin fenofibrate
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