摘要
目的评价多种宫颈癌筛查方式,为农村欠发达地区优选一种较适宜的筛查方法。方法在宫颈癌高发区山西省阳城县对744名年龄为20￣59岁已婚妇女,进行宫颈癌危险因素的流行病学问卷调查、阴道醋酸染色(VIA)、碘染色(VILI)及阴道镜检查并进行13种高危型HPVDNA的检测、收集阴道脱落细胞进行液基细胞学诊断,宫颈有病变者取可疑组织病检。数据用FoxPro6.0录入和整理后,运用SAS软件进行统计学处理和分析。结果CINI以上病例73人,普查人群检出率9.81%(73/744),其中CINⅠ41例,CINⅡ18例,CINⅢ13例,腺癌1例。HPV人群感染率15.99%(119/744)。以病理组织学为金标准(≥CINⅡ为阳性),各检查方法灵敏度和特异度分别为VIA(10.53,82.44),VILI(53.13,82.44),阴道镜检查(56.25,79.35)、液基细胞学(68.75,97.29)和HPV(93.75,87.50)。结论从经济性、适用性综合考虑,VILI在农村不发达地区是一种可行的筛查手段。
Objective To evaluate the screening use value for cervical cancer, select a better way to rural women. Methods In the areas of Yangcheng County,Shanxi province with high incidence of cervical cancer,744 women were interviewed using a risk factors questionnaire, all objects accepted visual inspection, VILI inspection, colposcopy, oncogenic human papillomavirus DNA testing and Pap smear inspect. Results The overall rates of HPV infection were 15.99 %（119/744）. Using pathology result as a gold standard（≥CINⅡ as positive ）the sensitivity, specificity of each diagnostic test listed as follows, HPV（93.75,87.50）, ThinPrep Pap（68.75,97.29）, colposcopy （56.25,79.35）, VILI（53.13,82.44）, Visual inspection （10.53,82.44）. Conclusions This study showed that VILI is both effective and feasible for screening cervical cancer in rural China.
出处
《肿瘤研究与临床》
CAS
2005年第4期287-288,共2页
Cancer Research and Clinic
