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异基因造血干细胞移植治疗白血病的临床研究 被引量：1

Treatment of leukemia by allogeneic hematopoietic stem cell transplantation
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摘要 目的探讨异基因造血干细胞移植治疗白血病。方法脐血移植治疗儿童白血病3例,异基因外周血造血干细胞移植治疗白血病3例。结果6例患者完全植入,+15～+25天白细胞(WBC)>1.0×109/L,+35天～+51天血小板(Plt)>20×109/L。例1出现急性GVHDⅠ度,例5出现急性GVHDⅣ度,例6出现肝静脉闭塞综合征(VOD)、急性GVHDⅠ度、出血性膀胱炎(HC),例2移植后6个月复发,放弃治疗死亡。余5例正常生活或工作。结论异基因造血干细胞移植治疗白血病是安全有效的方法。 Objective To investigate the application of allogeneic hematopoietic stem cell transplantation in the treatment of leukemia. Methods Three children with leukemia received unrelated umbilical cord blood transplantation（UBCT）. Three patient with leukemia received allogenic peripheral blood stem cell transplantation（PBSCT）. Results Hematopoietic function recovered to〉1.0×10^9/L of leukocyte on 15-25 days and to 〉20×10^9/L of platelet on 35-51 days in all patients. Case 1 had developed grades-Ⅰ GVHD. Grades-Ⅳ GVHD occurred in case 5. Case 6 had developed VOD, grades-Ⅰ GVHD, HC. Case 2 died of replase at six months after transplantation, the others are surviving. Conclusion Allogeneic hematopoietic stem cell transplantation（HSCT） is an effective and safe treatment for leukemia.
作者 王琳 史克珊 白志明 陈晓霞 王智明 刘春苗 罗贤生 吴琴 符容香 黄姿英 黄淑梅 黄海妹 黎丽琼 何丽莉 许振胜
机构地区 海口市人民医院血液科 中南大学湘雅医学院附属海口医院 海南省造血干细胞采集医院 海南省造血干细胞移植医院
出处 《白血病．淋巴瘤》 CAS 2005年第4期224-227,共4页 Journal of Leukemia & Lymphoma
关键词 白血病 造血干细胞移植 移植物抗宿主病 Leukemia Hematopoietic stem cell transplantation Graft-venus-host-disease
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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二级参考文献12

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共引文献17

同被引文献6

  • 1钟美佐,陈方平,徐雅靖,刘巍,赵谢兰.21例异基因外周血造血干细胞移植治疗白血病中GVHD防治的研究[J].中国现代医学杂志,2004,14(14):119-121. 被引量：3
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白血病．淋巴瘤
2005年 第4期

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