三维适形放射治疗中晚期非小细胞肺癌的临床观察

Three-dimensional Conformal Radiotherapy on Non-small Cell Lung Cancer

目的:观察三维适形放射治疗中晚期非小细胞肺癌的效果。方法:对200例中晚期非小细胞肺癌实施三维适形放射治疗,5～8Gy/次,隔日1次,肿瘤灶总剂量48～72Gy,随访6～42个月,平均24个月。结果:1、2、3年生存率分别为69.0%、48.0%和36.5%。治疗3个月后复查CT,肿块完全消失98例,缩小50%以上91例,不足50%11例。完全缓解98例,占49.0%;部分缓解102例,占51.0%;有效率100%。结论:三维适形放射治疗中晚期肺癌是一种有效的治疗方法,远期疗效仍待进一步随访证实。

Objective： To assess the response of three dimensional conformal radiotherapy （3D-CRT） on non-small cell lung cancer （NSCLC）. Methods： A total of 200 NSCLC patients were treated with the 3D-CRT, which was given every other day and 5 to 8Gy per fraction with the total doses from 48 to 72Gy. All cases were followed-up in 6 to 42 months, with average of 24 months. Results： Total survival rates of one, two and three year for the entire group was 69.0%, 48.0% and 36.5%, respectively. All the patients were reexamined in 3 months after treatment, mass disappeared in 98 patients, shrink over 50% in 91 patients and the other cases didn＇t shrink as half as before. The overall response rate （CR＋PR） was 100% for the primary tumor. Conclusion： The 3D-CRT is well tolerated in most patients with lung cancer and has produced a good responses. Further follow-up will be needed for confirmation of the long-term effect.