期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Expression and Significance of PTEN in Bladder Transitional Cell Carcinoma 被引量：1

PTEN在膀胱癌组织中的表达及其意义(英文)
下载PDF
导出
摘要 Objective： To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods： Using immunohistochemical S-P methods, the expression of PTEN gene was detected in 62 specimens of bladder cancer and 18 specimens of normal bladder tissue. Results： In the 62 bladder cancers, the positive rate of PTEN was 53.2% （33/62）. All 18 normal bladder tissues were positive for the PTEN expression. The expression of PTEN was negatively correlated to tumor grades （P〈0.05）. Conclusion： The reduced expression of PETN might play an important role in carcinogenesis and progression of bladder cancer. Detection of PTEN might be useful for judgement of tumor development and prognosis.
作者 张建华 杨为民 周四维
机构地区 武汉华中科技大学同济医学院附属同济医院泌尿外科
出处 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第4期218-220,共3页 中德临床肿瘤学杂志（英文版）
关键词 transitional cell carcinoma PTEN gene IMMUNOHISTOCHEMISTRY 基因表达 PTEN 膀胱过滤细胞癌 病理机制 疾病预后
分类号 R737.14 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Liu J, Babaian DC, Liebert M, et al. Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens. Mol Carcinog, 2000, 29:143-150.
  • 2Yang WM, Zhang HP, Yu X. The implication of the expression of three cytokines in carcinoma of bladder.Chinese-German J Clin Oncol, 2002, 1:98-101.
  • 3Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppression tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA, 1999, 96: 4240-4245.
  • 4Cairns P, Evron E, Okami K, et al. Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene, 1998, 16: 3215-3218.
  • 5Wu X, Obata T, Khan Q, et al. The phosphatidylinositol3 kinase pathway regulates bladder cancer cell invasion.BJU Int, 2004, 93: 143-150.
  • 6Tamura M, Gu J, Takino T, et al. Tumor suppressor PTEN inhibition of cell invasion, migration and growth:differential involvement of focal adhesion kinase and p130Cas. Cancer Res, 1999, 59: 442-449.
  • 7Gu J, Tamura M, Takino T, et al. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol, 1998, 143: 1375-1383.
  • 88 Huang J, Kontos CD. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem, 2002, 277: 10760-10766.
  • 9Tanaka M, Grossman HB. In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth,downregulates phosphorylated Akt, and increases sensitivity to doxorubicin. Gene Ther, 2003, 10:1636-1642.

同被引文献30

  • 1黄彬,姜傥.肾纤维化中上皮间充质转化的最新研究进展[J].国际检验医学杂志,2006,27(3):264-266. 被引量：17
  • 2程悦,李芙蓉,袁发焕.PTEN编码蛋白对TGF-β_1刺激大鼠肾成纤维细胞增殖的抑制作用[J].解放军医学杂志,2006,31(5):407-409. 被引量：6
  • 3Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [ J ]. Science 1997, 275 (5308) : 1943 - 1947.
  • 4Chu EC, Tarnawski AS. PTEN regulatory functions in tumor sup- pression and cell biology[ J]. Med Sci Monit,2004,10 (10) : 235- 241.
  • 5Ruan ZP, Xu R, Lv Y, et al. PTEN enhances the sensitivity of human hepatocellular carcinma cells to sorafenib [ J ]. Oncol Res, 2012,20(2 -3) :113 - 121.
  • 6Lee H, Choi HJ, Kang CS, et al. Expression of miRNAs and PTEN in endometrial specimens ranging from histologically normal to hyperplasia and endometrial adenocarcinoma [ J ]. Mod Pathol, 2012,25(11 ) :218 -220.
  • 7Simpson L, Parsons R. PTEN: life as a tumor suppressor[ J ]. Exp Cell Res,2003,264( 1 ) :29 -41.
  • 8M call P, Witton CJ, Grim sley S, et al. Is PTEN loss associated with clinical outcome measures in hunmn prostate cancer [ J ]. Br J Cancer,2008,99 ( 8 ) : 1296 - 1301.
  • 9Chung J H, Eng C. Nuclear - cytoplasmic partitioning of Phospha- tase and tensin homologue deleted on chromosome 10(PTEN) dif- ferentially regulates the cell cycle and apoptosis [ J ]. Cancer Res, 2005,65:8096 -8100.
  • 10Backman S, Stambolic V, Mak T. PTEN function in mammalian cell size regulation[J]. Curr Opin Neurobiol, 2002, 12(5) : 516 - 522.

引证文献1

The Chinese-German Journal of Clinical Oncology
2005年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部