头顶一棵珠抗炎和免疫作用的实验研究

Studies on anti-inflammatory and immune effect of tschnoskii maxim

目的 探讨头顶一棵珠的抗炎和免疫作用。 方法 抗炎实验采用巴豆油致小鼠耳廓肿胀等常规抗炎模型;免疫实验采用对小鼠体内碳粒廓清功能影响等的方法。结果 头顶一颗珠提取物可明显抑制巴豆油致小鼠耳廊肿胀及角叉菜胶引起的大鼠足跖肿胀,能显著抑制大鼠棉球肉芽肿的增重及2. 4 二硝基氯苯致小鼠迟发型超敏反应,明显增加免疫器官重量及指数,增强吞噬功能。结论 头顶一颗珠有明显的抗炎和免疫调节作用。

Aim To study the anti-inflammatory and immune effects of tschnoskii maxim. Mothods A few conventional models, such as the mouse pinna swelling induced by croton oil; immune experiment adopted carbo clearance in mice. Results Tschnoskii maxim obviously inhibited the swelling of mouse pinna induced by croton oil, suppressed the edema of rat hind paw swelling elicited by injection of 1% carrageenan,significantly depressed the increase of proliferation of granuloma led by implanting cotton pellet and the deleyed-type hypersensitivity （ DTH ） reactions reduced by DNCB. It markedly increased the weight of immune organs and indices enhanced phagocytosis function. Conclusion Tschnoskii maxim has the effects of anti-inflammatory and immune.