胚胎皮层神经元的迁移及其相关分子机制

Cell migration in the forebrain and the underlying molecular mechanism

在中枢神经系统发育中,皮层神经元的迁移是一个复杂而又被精确调控的过程.胚胎皮层神经元主要有两种迁移方式:来源于背侧端脑的锥体神经元主要采用放射状迁移;而来源于腹侧端脑的中间神经元则采用切线方向迁移进入皮层.其中,在皮层发育早期,锥体神经元直接以胞体位移运动向表面迁移;而在发育晚期,皮层相对较厚时,锥体神经元需借助放射状胶质细胞突起的导向作用迁移到目的部位.

During development of the mammalian telencephalon, cells migrate along distinct pathways and reach their final destinations. Pyramidal neurons are generated from cells that migrate radially from the ventrieular zone, while interneurons migrate tangentially from ventral ganglionic eminences to the developing cortex. During the process of radial migration, pyramidal neurons adopt soma transloeation at first, followed by glial-guided locomotion at the late stage of eortieogenesis. Here we summarize the routes of migration in the developing teleneephalon, with a particular focus on the radial migration.