摘要
本文探讨马齿苋多糖对S180荷瘤小鼠免疫功能的影响。马齿苋采用水提醇沉法得到马齿苋多糖,分别以50、100、200mg/kg通过腹腔给药10d,观察马齿苋多糖对S180荷瘤小鼠的抑瘤作用及对小鼠淋巴细胞转化功能、腹腔巨噬细胞的吞噬能力、白介素l(IL l)和白介素2(IL2)生成量的影响。结果显示,马齿苋多糖对S180荷瘤小鼠有明显的抑瘤作用,抑瘤率分别为16.92%、51.45%和64.96%。不同剂量马齿苋多糖与对照组相比可明显促进淋巴细胞的转化、小鼠腹腔巨噬细胞吞噬能力,可有效的增加荷瘤小鼠脾淋巴细胞的转化和腹腔巨噬细胞的吞噬能力以及白介素1(IL1)和白介素2(IL2)的分泌。说明马齿苋多糖对S180荷瘤小鼠具有显著的抗肿瘤作用,其作用机制与增强小鼠免疫作用有关。
In order to evaluate the effects of Portulaca oleracea polysaccharide (POP) on immune effects in Sarcoma180, the POP was obtained by water extraction and alcohol precipitation from Portulaca okeracea and was administered on the Sarcoma180 with 50 mg/kg, 100 mg/kg and 200 mg/kg respectively by intraperitoneal injection(IP) for 10 d. The inhibition rate of tumor growth,lymphocyte Proliferation phagocytic activity and IL-I IL-2 were investigated. The POP could significantly inhibit tumor growth;the inhibition rates of tumor growth were 16.92,51.45 and 64.96 (%). Compared with NS group ,the POP increased lymphocyte transformation capacity Phagocytic activity and the IL-1 and IL-2. secretion. The POP has obvious antineoplastic effect,and the main mechanism is to enhance the immune function of Sarcoma180.
出处
《天然产物研究与开发》
CAS
CSCD
2005年第4期453-456,共4页
Natural Product Research and Development
关键词
马齿苋
多糖
S180荷瘤
抗肿瘤
免疫功能
Porudaca oleracea
polysaccharide
Sarcoma180
antineoplastic effect
immune function.