臭灵丹水提取物的急性毒性及镇痛作用的实验研究(英文)

Acute Toxicity and Antinociceptive Effect of Laggera pterodonta(DC) Benth Aqueous Extract in Mice

采用上下移动法,醋酸扭体法、热板法、福尔马林致痛试验对臭灵丹水提取物的急性毒性及镇痛作用进行了研究。结果显示:臭灵丹水提取物LD50(腹腔注射)为1.19g/kg;臭灵丹水提取物明显抑制醋酸所致的小鼠扭体数,显著减少福尔马林致痛试验后期小鼠舔足行为;而对热板法所致疼痛无明显作用。表明臭灵丹水提取物具有一定的外周镇痛作用。

Acute toxicity and antinociceptive effect of the aqueous extract from Laggera pterodonta（AELP） were studied in mice. Antinociceptive activity was determined using writhing, hot plate and formalin tests in mice. The LD50 value of intraperitoneally injected aqueous extract of L. pterodonta in mice was 1.19 g/kg. Although the aqueous extract of L. pterodonta at an oral administration of 200 ～ 400 mg/kg had an antinociceptive effect on writhing responses induced by acetic acid,it was ineffective on nociceptive responses in the hot plate test. The extract of L. pterodonta significantly decreased the frequency of licking behavior within a unit of time at the late phase Without affecting that of the early phase in the formalin test. These results suggest that the aqueous extract from L. pterodonta possesses peripheral analgesic effect mediated by anti-inflammatory action.