植物多酚的防癌抗癌作用

Cancer Preventive Effect and Anti-cancer Activity of Plant Polyphenols

植物多酚是植物中广泛存在的一大类多酚化合物的总称,包括多酚(如单宁)、黄酮、酚酸等。体外实验研究表明植物多酚对多种人癌细胞具有增殖抑制作用,抑制动物体内肿瘤生长。其作用机理与抗氧化、调控细胞周期、诱导肿瘤细胞凋亡和分化、影响血管生成和肿瘤细胞信号传导等有关。对植物多酚的防癌抗癌作用,值得进一步深入研究。

Plant polyphenols consist of a number of plant-derived phenolic compounds, including polyphenols （e. g., tannins）, flavonoids, and phenolic acids, which have inhibitory effect on the proliferation of human cancer ceils in vitro and inhibit the growth of animal tumor models in vivo. Their mechanism of action is mainly involved in antioxidative effect, manipulating cancer cell cycle, inducing apoptosis and differentiation of cancer cells, regulating angiogenesis and signal transduction of cancer calls. The anticancer therapeutic and chemoprevention properties of plant polyphenols need to be investigated further.