重视瘦素在肝纤维化领域中的研究
Strengthening research on leptin in hepatic fibrosis
摘要
瘦素(leptin)是一种由肥胖基因编码的分泌型蛋白质,具有广泛的生物学效应.近年来的研究显示,瘦素与肝纤维化形成之间有密切联系.在慢性病毒性肝炎、酒精性肝硬化、原发性胆汁性肝硬化等患者中均可见血清瘦素水平异常.目前国内外研究主要集中于瘦素与活化肝星状细胞(HSC)间的关系、瘦素对细胞因子分泌的调控,以及瘦素对肝纤维化胶原产生及降解的影响.本文从流行病学入手,阐述瘦素促进肝纤维化形成的证据,以探讨瘦素参与肝纤维化的作用机制,强调瘦素在该领域中的研究已初见端倪,必须引起我们足够的重视.
出处
《世界华人消化杂志》
CAS
北大核心
2005年第15期1801-1803,共3页
World Chinese Journal of Digestology
参考文献43
-
1Houseknecht KL, Baile CA, Matteri RL, Spurlock ME. The biology of leptin: a review. J Anim Sci 1998;76:1405-1420.
-
2Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
-
3Clement K, Boutin P, Froguel P. Genetics of obesity. Am J Pharmacogenomics 2002;2:177-187.
-
4Boutin P, Froguel P. Genetics of human obesity. Best Pract Res Clin Endocrinol Metab 2001;15:391-404.
-
5Considine RV. Human leptin: an adipocyte hormone with weight-regulatory and endocrine functions. Semin Vasc Med 2005;5:15-24.
-
6Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M.Leptin promotes differentiation and survival of human dendritic cells and licenses them for Thl priming. J Immunol 2005;174:6820-6828.
-
7Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C.Effects of adipocyte-derived cytokines on endothelial functions:implication of vascular disease. J Surg Res 2005;126:121-129.
-
8Tasdelen A, Algin C, Ates E, Kiper H,Inal M, Sahin F. Effect of leptin on healing of colonic anastomoses in rats. Hepatogastroenterology. 2004;51:994-997.
-
9Peelman F, Iserentant H, Eyckerman S, Zabeau L, Tavernier J.Leptin, immune responses and autoimmune disease. Perspectives on the use of lepfin antagonists. Curr Pharm Des 2005;11:539-548.
-
10Matarese G, Sanna V, Fontana S, Zappacosta S. Leptin as a novel therapeutic target for immune intervention. Curr Drug Targets Inflamm Allergy 2002;1:13-22.
-
1李德,宋卫东.瘦素与骨关节炎[J].国际外科学杂志,2009,36(1):63-66.
-
2赵彩彦,姜玲玲,李建梅,梁保丽.酒精性肝病患者血清瘦素水平与肝纤维化的关系[J].中华肝脏病杂志,2003,11(11):694-695. 被引量:4
-
3张力,米杰.瘦素[J].中华预防医学杂志,2004,38(4):281-281. 被引量:1
-
4周小蕙,曹平.脂肪肝患者血清瘦素水平的测定及意义[J].山西医药杂志,2006,35(3):236-236. 被引量:1
-
5朱净,潘亮,许晶,陆静娴,黄华,陆翠华.瘦素及Ⅰ和Ⅲ型胶原蛋白在肝纤维化大鼠肝组织中的变化[J].基础医学与临床,2012,32(10):1224-1225. 被引量:4
-
6赵勤,李建飞,张红,贾卫鸿,伍贤平,廖二元,罗湘杭.血清瘦素与男性骨密度及体脂的关系[J].中华内科杂志,2007,46(7):582-583.
-
7张慧玲,成蓓.瘦素与心血管疾病[J].国外医学(心血管疾病分册),2002,29(5):265-267. 被引量:7
-
8王静,廖荣宏.瘦素在冠心病发病机制中的最新进展[J].现代医药卫生,2014,30(10):1494-1496. 被引量:5
-
9刘智勇,徐晶.瘦素与代谢综合征[J].中国保健,2009(31):1368-1370.
-
10武文峰,蔡鑫.瘦素与冠心病发病机制的研究进展[J].心血管病学进展,2008,29(3):416-418. 被引量:5