红花总黄素对实验性心肌缺血模型冠脉流量及血流动力学的影响

An Protective Effects and Mechanism of Safflor Yellow on Coronary Flux and Hemodynamics in Acute Myocardial Ischemia

目的:观察红花总黄素对实验性心肌缺血模型的影响,并探讨其与对抗氧自由基的关系。方法:采用异丙肾上腺素(10mg.kg-1)制备大鼠急性心肌缺血模型,随机分为对照组、红花总黄素(10,20mg和40mg.kg-1iv),行心导管插管术,观察血流动力学指标变化(MBP、LVSP、LVEDP、±dp/dtmax,等)。采用犬在位心脏测定冠脉流量法,分别观测给药前,给药后15,30,60min的冠脉流量和心肌耗氧量。结果:红花总黄素各组给药后15min均表现出不同程度的增加心脏冠脉流量(P<0.05或P<0.01),心肌耗氧量明显减少(P<0.05,P<0.01或P<0.001)。红花总黄素各组对心肌缺血大鼠血流动力学有明显改善作用(P<0.05或P<0.01)。结论:红花总黄素能增加冠脉流量,减少心肌耗氧量,并表现出剂量相关性变化。

Objective： To observe the effect of safflor yellow on the experimental myocardial ischemia model and investigate the relationship between safflor yellow and oxygen free radicals. Methods： Acute myolardial ischemia （AMI） model were induced by isoproterenol（10 mg · kg^-1 ）. The changes of indexes on hemodynamics in rats were observed, such as MBP, LVDP, LVEDP and ±dp/dtmax. Results： Compared with conrtol group, the content of MDA and the activity of SOD in the heart muscle decreased in safflor yellow （20 mg,40 mg · kg ^-1 ）groups（P〈0.05 or P〈0.01）. Conclusion：We can see that safflor yellow can decrease in HR significantly and improve the index of hemodynamics.