酸枣仁不同炮制品及炒酸枣仁中总黄酮与总皂苷的镇静催眠作用比较

Comparative Studies on the Sedative and Hypnotic Effect of the Crude and Processed Semen of Ziziphi Spinosa, and the Effect of Total Flavonoid and Saponin

目的:研究比较酸枣仁生品和炒品及总黄酮和总皂苷的镇静催眠作用。方法:采用小鼠活动记数法和协同阈下剂量戊巴比妥钠镇静催眠法。结果:酸枣仁生品以20g/kg剂量及酸枣仁炒品以10g/kg剂量灌胃给药,可显著减少小鼠自发活动次数;酸枣仁生品和炒品以10g/kg和20g/kg剂量灌胃给药均可协同阈下剂量戊巴比妥钠使入睡小鼠数目显著增多。总皂苷以240mg/kg和480mg/kg剂量给药可显著减少小鼠自发活动次数,以480mg/kg剂量给药可显著增加阈下剂量戊巴比妥钠所致翻正反射消失小鼠数;总黄酮以300mg/kg剂量给药可显著减少小鼠自发活动次数、增加阈下剂量戊巴比妥钠所致翻正反射消失小鼠数。结论:酸枣仁生品和炒品均有抑制小鼠自发活动及协同戊巴比妥钠镇静催眠作用,且炒酸枣仁中总黄酮和总皂苷均有抑制小鼠自发活动和协同戊巴比妥钠镇静催眠作用。

Objective：To study the pharmacological effect of the crude and parched semen of Ziziphi Spinosa; To compare the effect between the total flavonoid and saponin from the parched semen. Methods： To observe the spontaneous motion and hypnosis in mice. Results：The crude and parched semen of Ziziphi Spinosa, and the sections from the parched semen could inhibit spontaneous motion and promote sleep coordinating with pentobarbital sodium of subthreshold dose. Conclusion：Both the crude and parched semen, both the total saponin and the total flavonoid are effective for sedative and hypnotic effects.