含羟基喜树碱联合化疗方案治疗晚期胃肠道癌临床观察

Clinical Observation of Treating Gastroenteric Carinoma with the Combinated Chemotherapy with Hydroxycamptothecin

目的:观察含羟基喜树碱(HCPT)联合化疗(PF)方案对晚期胃肠道癌的疗效和毒性反应。方法:86例患者随机分为含HCPT的治疗组和不含HCPT的对照组,其它PF药物均相同。所有患者均至少完成2个周期以上PF。结果:含HCPT的治疗组总有效率为48.8%,对照组有效率为32.6%,有显著性差异(P<0.05)。两组主要毒性反应无明显增加。结论:HCPT方案联合化疗治疗晚期胃肠道癌,有效率高,毒副反应无明显增加,值得在临床中推广使用。

Objective： To study the efficacy and toxicity in combination chemotherapy with hydroxycamptothecin（HCPT） in advanced gastroenteric carinoma. Methods： 86 patients were randomly derided into two groups： the treatment group received a combined therapy of cisplatin, leucorin,5-fiuorouacil plus hydroxycamptothecyi, and the control group received cisplatin,leucorin,5-fiuorouracil without hydroxycamptothecin. The efficacy and toxicity in two groups were evaluated after two cycles. Results：The overall response was 48.8% in the treatment group and 32.6% in control group. There was significant difference between the two groups. The major toxicity of two groups included anorexia, vomiting, leukopenia, but there was significant difference between the two groups. Conclusion：The combination chemotherapy with HCPT is effective and safe for gastroenteric carcinoma.