摘要
目的 探讨左旋卡尼汀对维持性血液透析患者微炎症状态的影响。方法 将42例维持性血液透析患者随机分为两组,试验组21例,对照组21例。每次透析后,试验组给予静脉注射左旋卡尼汀1g,对照组给予静脉注射生理盐水5ml,试验时间为3个月。结果 试验结束时,试验组IL-6、CRP含量明显降低,白蛋白、转铁蛋白水平升高,差异均具有统计学意义(P〈0.05),而对照组各项指标试验前后无明显改变。结论 左旋卡尼汀可降低维持性血液透析患者IL-6、CRP浓度,升高白蛋白、转铁蛋白浓度,改善患者营养及微炎症状态。
Objective To study the serum level changes of IL-6, CRP, albumin and transferrin in maintenance hemodialysis patients before and after L-carnitinc treatment. Method Forty-two stable maintenance hemodialysis patients in our dialysis center were enrolled. Patients were randomly divided into carnitine group and control group. In the treatment group, 1g L-carnitine was given intravenous to the patients at the end of each dialysis treatment, the patients in the control group were given normal saline, the trial lasted for 3 months. Results The IL-6,CRP,albumin and serum transferrin level singnificantly improved in treatment group(P〈0. 05). All the markers in the control group did not change throughout the trial. Conclusions L-carnitine can reduce serum levels of IL-6,CRP and increase albumin and transferrin and can improve the microinflammatory state in maintenance hemodialysis patients.
出处
《临床肾脏病杂志》
2005年第4期153-154,共2页
Journal Of Clinical Nephrology