醛固酮合成酶基因-344T/C多态性与高血压病相关性研究

Association between CYP11B2 gene-344T/C polymorphism and essential hypertension

目的研究醛固酮合成酶基因-344T/C多态性是否与原发性高血压相关。方法多聚酶链反应-限制性片段长度多态性技术检测原发性高血压和对照组醛固酮合成酶基因-344T/C多态性,χ2检验比较各组基因型和等位基因频率。结果对照组TT、TC和CC基因型频率分别为48%、43%和9%,高血压病组TT、TC和CC基因型频率分别为43%、47%和10%;对照组T、C等位基因频率分别为69%和31%,高血压病组T、C等位基因频率分别为66%和34%。经χ2检验两组之间基因型和等位基因频率差异均无显著性(P>0.05)。结论本研究尚不支持醛固酮合成酶基因-344T/C多态性与原发性高血压存在相关性。

Objective：To investigate whether the - 344T/C polymorphism of CYP11B2 gene is associated with essential hypertension in Hart nationalities, Methods： - 344T/C polymorphism was determined by polymerase chain reaction- restricted fragment length polymorphism （PCR- RFLP） in controls and hypertensives. Results ：No significant differences were found in genotype distribution or allele frequency between groups of control and primary hypertension（ P 〉 0.05 ）, Conclusion：No relationship was found between the - 344T/C polymorphism of CYP11B2 gene and essential hypertension in Han nationalities.