不孕及反复流产患者血清抗心磷脂抗体的检测

Determination of anticardiolipin antibodies in serum in patients with infertility or recurrent abortion

目的检测不孕及反复流产患者血清中的抗心磷脂抗体(ACA),探讨ACA的临床意义。方法应用酶联免疫吸附(ELISA)法检测105例原发或继发不孕患者(不孕组)、171例反复流产或有胚胎停育史患者(流产组)及40例正常对照组血清中的IgG、IgM及IgA-ACA3种抗体。结果不孕组ACA总阳性率为44.76%,流产组为35.09%,均显著高于对照组(P<0,01)。不孕组及流产组的单纯IgG阳性率亦明显高于对照组(P<0.05);而两组的单纯IgM阳性率与对照组相比,差异均无显著性意义(P>0.05)。结论ACA是导致不孕及反复流产的免疫学因素之一。

Objective：To study the role of anticardiolipin antibody （ACA） in patients with infertilhy or recurrent abortion. Methods：Serum ACA including three classes of IgG,IgM and IgA were detected by ELISA for 105 cases of primary or secondary infertility （infertility-group）, 171 of recurrent abortion or embryonic dispause （abortion group） and 40 normal women （control group）, Results：The positive rates of total ACA in infertility group and abortion group were 44,76 % and 35.09% respectively, which were very significantly higher compared with that in them control group （ P 〈 0.01 ） .The positive rates of pure IgG in the two study groups were also significantly higher compared with that in the control group（ P 〈 0.05 ）. And in the positive rates of pure IgM, no significant differences were found between the two study groups and the control group（ P 〉 0.05 ）. Conclusion ： ACA as one of the inmmnological factors play an important role in the process of infertility and recurrent abortion. IgG - ACA is more of clinical significance than IgM - ACA,