摘要
目的:探讨甜瓜藤有效部位(MVEP,melonvineseffectivepart.)抗肿瘤作用并初步探讨其抗肿瘤机制,为其临床应用提供实验室依据。方法:将接种肿瘤后的小鼠随机分为5组,每组10只小鼠,雌雄各半,给药10d,停药后24h处死动物,称鼠体重,剥离小鼠右腋下皮下组织,摘出肿瘤,称瘤重,测定生化指标。结果:对肉瘤(S180)、肝癌(Hep)、胃癌(MFC)细胞荷瘤小鼠肿瘤生长具有明显的抑瘤作用,其中对S180作用显著,较低剂量即可显示明显作用;延长S180荷瘤鼠生存时间;同时可增加吞噬指数a、廓清指数k及胸腺系数;对体外淋巴细胞转化功能亦有增强作用。结论:MVEP具有明显抗肿瘤活性。
Objective: Discuss about the anti-tumor effect and mechanism of MVET, which provides the basis of clinical application. Method: Divide mice (injected by tumor cell) into 5 groups randomly, each group has 10 mice, in which both male and female take one half. Administer MVET 10 days continuously. 24h after administration, kill and weigh them. Separate and weigh tumors in right axillary fossa in mice. Result: MVET inhibit growth of sarcoma S 180, liver carcinoma HEP and gastric carcinoma MFC cell bearing tumor mice obviously, it can suppress the growth of S 180 significantly and prolong the survival time even at a lower dose. Meanwhile, it can increase the phagocyte index A, expuragation index K, thymus coefficient and increase the transform function of the lymphocyte in vitro. Conclusion: MVET has obvious anti-tumor effect.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2005年第8期394-398,共5页
Food Science
基金
长春市科技局新星创业计划项目(长科技合(2004283)号)
关键词
甜瓜藤有效部位
抗肿瘤
melon vines effective part(MVET)
anti-tumor