薯蔓黄酮和多糖体内抗氧化作用研究

Studies on Antioxidant Effect in vivo of FSPV and PSPV

研究了薯蔓黄酮(FSPV)和薯蔓多糖(PSPV)对小鼠体内抗氧化作用。采用试剂盒分别测定小鼠血清、心、肝、肾组织中MDA和LPF含量、SOD和GSHpx酶活性和TAOC。研究结果表明,FSPV可显著或极显著降低血清及各组织中MDA和LPF含量,提高TAOC,但对SOD和GSHpx活性无显著影响;PSPV可显著或极显著地提高SOD和GSHpx活性和TAOC,并降低MDA和LPF含量。虽然作用机制不同,但FSPV和PSPV都能有效地提高机体组织抗氧化能力,防止组织脂质的过氧化损伤。

To study the antioxidant effect in vivo of FSPV and PSPV on mice, contents of malondiadehyde（MDA） and lipofuscin （LPF）, enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSHpx） and the total antioxidant competency （TAOC） in the serum, heart, liver and kidney of mice were measured by reagent box. The followings are results. FSPV can significantly or remarkably significantly decrease the contents of MDA and LPF and increase TAOC in tested tissues, but having no obvious influence on the activity of SOD and GSHpx. PSPV can increase significantly or remarkably significantly the TAOC and activity of SOD and GSHpx and decrease the contents of MDA and LPF in tested tissues. Although the mechanism is different, both FSPV and PSPV can increase the antioxidant action in vivo significantly and prevent lipid peroxidation damages in tested tissues.