摘要
CCL27是一种CC型趋化因子,其配体为CCR10。由于mRNA剪切的不同,CCL27形成两种不同的分子,即经典CCL27和其变异体PESKY,前者含分泌肽,对活化CD4+T细胞有趋化作用,是皮肤炎症反应中扮演主要角色的趋化因子;后者含有核内定位序列,调控细胞骨架结构的重排,这一特性为该趋化因子所独有,可能预示着趋化因子家族的新功能。
CC chemokine ligand 27 （CCL27）, through interaction with its cognate receptor, CC chemokine receptor 10 （CCR10）, involved in attracting a subset of CD4^＋ T cells to the skin during some cutaneous inflammatory responses. Strangely, CCL27 can also be produced as a non-secreted form, as a result of alternative splicing. This protein, termed PESKY, is targeted to the nucleus where it is able to modulate transcription and alter cell morphology. Specifically, PESKY induces a rearrangement of the actin cytoskeleton. Such character is sole in chemokine family and may foreshow new function of chemokine in immune response.
出处
《生命科学》
CSCD
2005年第4期308-310,共3页
Chinese Bulletin of Life Sciences
基金
上海市科委优秀学科带头人计划(04XD14003)
国家教育部科学技术重点项目(03063)资助
