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SATB1在基因表达调控中作用的研究进展 被引量：1

Research advances of SATB1 on gene expression and regulation
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摘要 SATB1是一种组织特异性的核基质结合蛋白,参与了染色质高级结构的形成和组织特异性基因的表达调控,对于胸腺细胞的发育和T细胞的成熟起到了尤为重要的作用。虽然已经知道SATB1可以通过与MAR序列结合,以促进染色质重塑,调节组蛋白乙酰化和甲基化水平等多种途径对基因的表达进行调控,但是对于该过程所涉及到的分子机制仍然不是很清楚。本文对SATB1在基因表达调控方面的研究进展作一综述。 SATB1 is a tissue-specific MAR binding protein which participates in the chromatin higher structure package and tissue-specific gene expression, and also plays a vital role in maturation of thymocyte and development of T cells. Although we have already understood that SATB1 can regulate the gene expression through chromatin remodelling, histone acetylation and methylation, the related molecular mechanism still has not been unveiled. This review focuses on the recent research advances of SATB1.
作者 李珂 卢健
机构地区 上海第二医科大学生物化学和分子生物学教研室人类基因研究中心
出处 《生命科学》 CSCD 2005年第4期315-317,共3页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金(No.39970311) 上海市科委重点项目(No.01JC14025)
关键词 SATB1 MAR 染色质重塑 SATB1 MAR chromatin remodelling
分类号 Q51 [生物学—生物化学] Q786 [生物学—分子生物学]
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参考文献12

  • 1Dickinson L A, Joh T, Kohwi Y, et al. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell, 1992, 70:631～645.
  • 2Alvarez J D, Yasui D H, Niida H, et al. The MAR-binding protein SATB 1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev,2000, 14(5): 521～535.
  • 3Dickinson L A, Dickinson C D, Kohwi-Shigematsu T. An atypical homeodomain in SATB 1 promotes specific recognition of the key structural element in a matrix attachment region. J Biol Chem, 1997, 272(17): 11463～11470.
  • 4李颖,仇全,卢健.核基质结合区结合蛋白质1——SATB1[J].生命的化学,2003,23(6):413-416. 被引量：2
  • 5Cai S, Han H J, Kohwi-Shigematsu T. Tissue-specific nuclear architecture and gene expression regulated by SATB 1. Nat Genet, 2003, 34:42～50.
  • 6Yasui D, Miyano M, Cai S, et al. SATB 1 targets chromatin remodelling to regulate genes over long distances. Nature,2002, 419:641～645.
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  • 9Kieffer L J, Greally J M, Landres I, et al. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB 1 and GATA-3. J Immunol, 2002, 168(8): 3915～3922.
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共引文献1

同被引文献11

  • 1Alvarez J D,Yasui D H,Niida H,et al. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev, 2000, 14 (5): 521-535.
  • 2Hye-Jung Han, Jose Russo, Yoshinori Kohwi, et al. SATB1 repro-grammes gene expression to promote breast tumour growth and metastasis. Nature ,2008,452 : 187-193.
  • 3Kazuko Nishikura, A Short Primer on RNAi:RNA - Directed RNA Polymerase Acts as a Key Catalyst. Cell,2001,107:415-418.
  • 4Wiznerowicz M,Trono D. Conditional suppression of cellular genes: Lentivirus vectormediated druginducible RNA interference. J Virol, 2003,77 (16) : 8957-8951.
  • 5Tiscomia G, Singer O, Verma IM. Production and purification of lentiviral vector. Nat Protoc ,2006,1 (1) :241-245.
  • 6Dickinson L A, Joh T, Kohwi Y, et al. A tissue-specific MAR/SAR DNA -binding protein with unusual binding site recognition. Cell, 1992,70:631-645.
  • 7Dickinson L A, Dickinson C D, Kohwi-Shigematsu T. Anatypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region. Biol Chem, 1997,272 (17) :11463-11470.
  • 8Cai S, Hart H J, Kohwi-Shigematsu T. Tissue-specific nuclear archi-tecture and gene expression regulated by SATB1. Nat Genet,2003, 34:42-50.
  • 9Sena-Esteves M, Tebbets JC, Steffens S, et al. Optimized large-scale production of high titer lentivirus vector pseudotypes. Virol Meth- ods,2004,122 : 131-139.
  • 10Reiser J. Production and concentration of pseudotyped HIV-l-based gene transfer vectors. GeneTher,2000 ,7( 11 ) :910-913.

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生命科学
2005年 第4期

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