对甲苯磺酸催化合成癸二酸二乙酯

Synthesis of diethyl sebacate catalyzed by p-toluene sulfonic acid

在对甲苯磺酸存在下,由乙醇和癸二酸合成了癸二酸二乙酯,当癸二酸、乙醇和对甲苯磺酸的物质的量之比为1∶8∶0.31,环己烷为带水剂,回流分水60min,该酯收率达96.9%.该法具有操作方便、反应温和、产品纯度和收率高的优点.

Diethyl sebacate is a synthesis from ethyl alcohol and sebacic add in the presence of p - toluene sulfonic acid. The yield of the ester could reach 96.9 % when the amount of substance ratio of sebacic acid, ethyl alcohol and p- toluene sulfonic acid is 1：8：0.31, with cyclohexane as water carrier being refluxed and water being segrated for 60 min. This method has the advantages of simple operation, mild reaction conditions, high purity and yield.