摘要
生物转化具有底物选择性、立构选择性、化学选择性、对映选择性等一般化学反应中不具备的优点,在精细化工中占有很大的优势,其中Baeyer-Villiger氧化反应在生物转化中占有很重要的地位,产生的许多中间体或产物可以被用来生产多种化学产品和药物,在工业生物催化中有很好的应用前景。本文主要对生物转化中的Baeyer-Villiger氧化反应在利用酶或细胞作为催化剂时存在的问题和解决方法以及基因技术的运用近况进行了综述。
Biotransformations have many attractive characters, such as substrate- , stereo-, chemo- and enantioselectivity, so they have a great advantage in the fine chemical industry. Baeyer-Villiger axidation is an important chemical conversion and the products and intermediates can be used to lot of medicine and fine chemicals, so it has a bright prospect in the industrial biological catalysis. This article mainly summarizes the state-of-the-art situation for the problem and solutions when isolated enzymes or intact cells are used as catalysts in Baeyer-Villiger oxidations as well as the application of gene technology in Baeyer-Villiger oxidations.
出处
《世界科技研究与发展》
CSCD
2005年第4期79-83,共5页
World Sci-Tech R&D
基金
中国科学院知识创新工程重要方向项目基金资助(No.KSCX2-SW-114)。
