摘要
目的观察萘哌地尔治疗慢性前列腺炎的疗效,探讨其作用机制。方法将136例慢性前列腺炎患者随机分为两组各68例,治疗组口服萘哌地尔25mg,每晚睡前服用1次,同时合用左氧氟沙星0.2g,早晚各1次;对照组仅口服左氧氟沙星0.2g,早晚各1次,均治疗6周。比较两组治疗前后前列腺液常规检查、前列腺炎症状评分、平均尿流率、最大尿流率、最大尿道闭合压、最大尿道压和残余尿量的变化。结果治疗组在降低前列腺液中白细胞计数、前列腺炎症状评分、最大尿道闭合压、最大尿道压和残余尿量以及提高平均尿流率和最大尿流率方面均优于对照组(P<0.05)。结论萘哌地尔可降低尿道压力,减少前列腺内尿液反流,明显改善前列腺炎患者症状,尤其适用于并发有功能性尿路梗阻症状的患者。
Objective To observe the effect of naftopidil tablets in the treatment of chronic prostatitis and to study the mechanism in the treatment. Methods 136 patients with chronic prostatitis were randomly divided into two groups evenly： the treatment group treated with naftopidil tablets （ 25 mg, qn） and levofloxacin （0.2 g, bid） and the control group treated only with levofloxacin （0.2 g, bid ） for 6 weeks. Prostatic secretion examination （ EPS）, chronic prostatitis symptom index （ CPSI）, average flow rate（ AFR）, maximum flow rate （MFR）, maximum urethral closure pressure（ MUCP）, maximum urethral pressure （MUP） and residual urine （RU） were compared. Results The differences between the two groups were significant in EPS, CPSI, AFR, MFR, MUCP, MUP and RU （P〈0.05）. Conclusion Naftopidil tablets can lower the intraurethral pressure, reduce intraprostatic urinary reflux and improve the symptoms of chronic prostatitis, especially for those with the symptoms of functional urinary tract obstruction.
出处
《医药导报》
CAS
2005年第9期769-770,共2页
Herald of Medicine
