强迫症患者神经认知功能研究

A Preliminary Study of Cognitive Dysfunction in Obsessive- compulsive Disorder

目的:探讨强迫症认知功能障碍的特点。方法:采用韦氏记忆量表(WMS)、数字划销测验(NCT)、威斯康星卡片分类测验(WCST)评估记忆、注意、执行功能。结果:强迫症WMS中的1-100、长时记忆、记图、再生、联想、触摸、理解、短时记忆和记忆商均显著性较正常组差。强迫症NCT中的净分、第一、第三、第四、第五阶段划对数和第一、四阶段失误率均显著性较正常组差;强迫症WCST中的总正确数、总错误数、持续性错误、非持续错误均显著性较正常组差。结论:强迫症的长时记忆、短时记忆、记忆商数、注意及执行功能均显著性较正常人差,其瞬时记忆无明显损害。

Objective： To explore the characteristics of cognitive dysfunction in OCD. Methods： Wechsler Memory Scale（WMS）, Number cancellation test（NCT）, wisconsin card sorting test（WCST） were used to assessed Memory, attention, executive function of OCD patients. Results： OCD patients did significantly worse than normal controls on 1-100, longterm memory, figure recall, regeneration,association, touch, story, reciting number, and memory quotient （MQ） of WMS. There were no significant differences between two groups on 100-1, accumulation, recognize and immediate-term memory of WMS. Total score and accurate cancellation scores on the first, third, fourth, fifth cancellation task and error rate on the first, fouth cancellation task of Number cancellation test （NCT） and total corrects, total errors, perseverative errors and random errors of WCST in OCD patients were significant worse than that in normal controls. Conclusion： The performance of OCD patients was significantly worse than normal controls in long-term memory, short-term memory. MQ. attention. executive function. Immediate-term memory was not impaired in OCD patients.