脑膜瘤中整合素β_1的表达及其生物学意义

Expression of Integrin-β_1 in Meningiomas and Its Biological Significance

目的探讨脑膜瘤中整合素β1的表达及其生物学意义。方法用免疫组化方法检测43例脑膜瘤、5例正常硬脑膜及5例正常蛛网膜中整合素β1的表达。结果整合素β1在WHOⅠ级及WHOⅡ、Ⅲ级脑膜瘤中的免疫组化阳性率分别为40.0%及87.5%,有明显差异(P<0.05);在侵袭性脑膜瘤中的表达明显高于在非侵袭性脑膜瘤中的表达(P<0.01)。结论整合素β1参与脑膜瘤的增殖调控,随着整合素β1表达的增高,肿瘤细胞的增殖活性升高,恶性程度增加;并与脑膜瘤的侵袭性有关。

Objective To investigate the expression of integrin-β1 in meningiomas and its biological significance. Method Immunohistochemical technique was used to determine the expression of integrin-β1 in 43 eases of meningioma, 5 cases of normal dura mater and 5 cases of normal arachnoid membrane. Results The positive expression rate（87.5%） of integrin-β1 in grades Ⅱ - Ⅲ meningiomas was significantly higher than that （40.0%） in grade Ⅰ meningiomas （P〈0.05）, The positive expression rate of integrin-β1 in the invasive meningiomas （90.0%） was significantly higher than that （36.36%） in the non-invasive meningiomas （P〈0.01）. Conclusion Integrin-β1 participates in the process of meningiomas proliferation. The proliferative activity and malignant degree of meningiomas are correlative to increase in the expression of integrin-β1. The integrin-β1 expression is associated with the invasiveness of meningiomas.