Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas

瞄准：最近的实验室和流行病学的研究建议维生素Ｄ是为颜色的一个潜在的代理人表面的癌症预防。它的功能被维生素Ｄ受体(VDR ) 部分调停。这研究的目的是调查是否新奇 G (等位基因 "U")】A (等位基因 "u") 在 VDR intron 的多型性(Tru9I ) 8 区域为颜色与风险被联系在基于 colonoscopy 的盒子控制研究的表面的腺瘤。方法：为 391 个题目的一个总数的 Genotyping 通过 PCR 和限制碎片长度多型性被执行。结果："U" 和 "u" 等位基因的频率分别地是 89.3% 和 10.7% 。"Uu" 和 "uu" 遗传型为腺瘤与减少的风险被联系(或， 0.71；95%CI， 0.40-1.25 ) 。反的协会为多重腺瘤是更显著的，更大的腺瘤有中等或更大的发育异常，或是无柄的：机会比率(ORs ) 是， 0.51 (95%CI， 0.21-1.24 ) ， 0.37 (95%CI， 0.11-1.28 ) ， 0.68 (95%CI， 0.33-1.41 ) ，并且 0.36 (95%CI， 0.13-0.97 ) 分别地。在连接 / 联合的分析，反的协会在有至少一 "u" 等位基因的那些之中并且也是更明显的更年轻(或， 0.60；95%CI， 0.26-1.37 ) ，女人们(或， 0.38；95%CI， 0.17-0.88 ) ，没吸烟(或， 0.39；95%CI， 0.13-1.23 ) ，或拿了 NSAID (或， 0.38；95%CI， 0.12-1.25 ) ，但是没有证据为和钙或维生素Ｄ吸入的相互作用存在。结论：我们的调查结果建议 VDR Tru9I 多型性可以为颜色与更低的风险被联系表面的腺瘤特别地在和各种各样的风险因素的相互作用，然而并非与钙或维生素Ｄ。

AIM： Recent laboratory and epidemiological studies suggest that vitamin D is a potential agent for colorectal cancer prevention. Its function is partially mediated by the vitamin D receptor （VDR）. The aim of this study was to investigate whether a novel G （allele ‘U’g〉A （allele ‘u’ polymorphism （Tru9I） in the VDR intron 8 region is associated with risk for colorectal adenoma in a colonoscopy-based case-control study. METHODS： Genotyping for a total of 391 subjects was carried out through PCR and restriction fragment length polymorphism. RESULTS： The frequencies of ‘U’ and ‘u’ alleles were 89.3% and 10.7%, respectively. The ‘Uu’ and ‘uu’ genotypes were associated with decreased risk for adenoma （OR, 0.71; 95%CI, 0.40-1.25）. The inverse association was more pronounced for multiple adenomas and adenomas that were larger had moderate or greater dysplasia, or were sessile： the odds ratios （ORs） were, 0.51 （95%CI, 0.21-1.24）, 0.37 （95%CI, 0.11-1.28）, 0.68 （95%CI, 0.33- 1.41）, and 0.36 （95%CI, 0.13-0.97） respectively. In joint/ combined analyses, inverse associations were more obvious among those who had at least one ‘u’ allele and also were younger （OR, 0.60; 95%CI, 0.26-1.37）, women （OR, 0.38; 95%CI, 0.17-0.88）, did not smoke （OR, 0.39; 95%CI, 0.13-1.23）, or took NSAID （OR, 0.38; 95%CI, 0.12-1.25）, but no evidence existed for interactions with calcium or vitamin D intake.CONCLUSION： Our findings suggest that the VDR TrugI polymorphism may be associated with lower risk for colorectal adenoma, particularly in interaction with various risk factors, but not with calcium or vitamin D.