异常妊娠史妇女人巨细胞病毒感染的研究

STUDY OF HUMAN CYTOMEGALOVIRUS INFECTION IN ABNORMAL PREGNANT WOMEN

采用间接ＥＬＩＳＡ检测１０５例异常妊娠史妇女和３０例正常孕妇人巨细胞病毒（ＨＣＭＶ）ＩｇＭ和ＩｇＧ抗体（（ＨＣＭＶ－ＩｇＧ和ＨＣＭＶ－ＩｇＭ）阳性率，并做了比较。结果表明：异常妊娠史妇女ＨＣＭＶ－ＩｇＧ阳性率９６．２％，正常孕妇ＨＣＭＶ－ＩｇＧ阳性率９０％，统计学处理，无显著性差异（Ｐ＞０．０５）；异常妊娠史妇女ＨＣＭＶ－ＩｇＭ阳性率２８．６％，正常孕妇ＨＣＭＶ－ＩｇＭ阳性率１０％，经统计学处理，有显著性差异（Ｐ＜０．０５）。ＨＣＭＶ活动性感染与妊娠异常、胎儿先天性畸形关系密切。同时采用间接ＥＬＩＳＡ检测ＨＣＭＶ－ＩｇＧ和ＨＣＭＶ－ＩｇＧ为预测、监视胎儿先天畸形提供了早期诊断依据。

Human cytomegalovirus (HCMV) IgG and IgM anti bodies were detected by indirect ELISA in 105 serum specimens from women with history of abmormal pregnancy and 30 normal pregnant women. The results showed that the positive rate of HCMV-IgG was 90% in normal women and 96. 2% in abnormal pregnant women (P>0.05), and the positive rate of HCMV-IgM was 28.6% in abnormal pregnant women, and 10% in normal groups(P <0. 05). Thus detecting HCMV-IgM by ELISA could be used not only in early diagnosis of active HCMV infection, but also in prevention of delivery of mallormed babies.