一种新型的蛋白质及多肽胍基的聚乙二醇化试剂的合成

A Novel PEGylation Reagent for Guanidine of Arginine in Protein

合成了一种新型的蛋白质及多肽胍基的PEG化试剂,其化学本质为mPEG单取代的乙酰丙酮,用于改造蛋白质及多肽的溶解性、稳定性、免疫原性和蛋白质多肽药物的体内循环时间。该方法提供的PEG化试剂主要针对蛋白质及多肽中精氨酸的胍基,具有广阔的应用前景。

A novel PEGylation reagent, mPEG-acetylacetone, was synthesized and used to modify protein such as recombinant interferon α-2b that contains arginine residues. It only reacts with guanidine of arginine and results in special mo.dification of some protein.