摘要
长期以来,人们普遍认为D型氨基酸在高等生物中没有功能。但最近10年的研究表明,D丝氨酸不但能够被胶质细胞合成和分泌,而且能够作为共激活因子,作用于NMDA受体的“甘氨酸位点”,参与该受体的激活。该文对D丝氨酸在中枢神经系统的产生、代谢和作用进行了简要介绍。
D-amino acids were believed to have no function in higher organisms several years ago. Recently, D-serine was proved to be synthesized by astrocytes in vivo and be released to work as an effective coagonist at the “glycine-binding” site of the N-methyl-D-aspartate (NMDA) glutamate receptors in central nervous system. In this paper, the synthesis, metabolism and function of D-serine were reviewed briefly.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第8期910-913,共4页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展规划(973计划)(No2004CB518907)
军事医学科学院创新启动基金
毒物药物研究所青年启动基金(No2004D0302)资助项目