左氧氟沙星联合化疗对28例复治肺结核的临床观察

The Clinical Observation of Levofloxacin Combined with Chemotherapy in Treatment of 28 Cases of Retreated Tuberculosis

目的观察左氧氟沙星联合化疗治疗复治肺结核的临床效果。方法将56例复治肺结核患者随机分为2组,28例采用左氧氟沙星联合化疗为治疗组,28例采用标准DOTS方案治疗为对照组。治疗一年间,留取两组患者痰液行结核分枝杆菌涂片检查,并观察两组3、6、12个月的痰菌阴转率和12个月时的X线吸收好转率。结果治疗组3、6、12个月患者痰菌阴转率分别是53.6%、75.0%、82.0%,对照组3、6、12个月痰菌阴转率分别是17.9%、32.0%、40.0%;两组12个月X线吸收好转率分别为89.3%、46.4%。两组比较,痰菌阴转率及X线吸收好转率差异均有显著性(P<0.01)。结论左氧氟沙星联合化疗治疗复治肺结核有明显优势。

Objective：To observe the effect of levofloxacin combined with chemotherapy on resistant tuberculosis. Methods： From Dec. 2003 to Dec. 2004. They were 56 cases of retreat tuberclosis in our hospital. They were randomly assigned to two groups. 28 cases of treatment group received levofloxacin combined with chemotherapy; 28 patients of contrast group received DOTS. After a year of treatment, mycobaterium tuberculosis form sputum from the patient was collected and then analyzed to evaluate the negative conversion rate of sputum after 3、6 and 12 months treatment and X-ray improvements rate after 12 months treatment. Results： In treatment group, the sputum negative conversion rates in 3、6 and 12 months were 53.6%、75.0% 、82.0% , but in contrast group the sputum negative conversion rates in 3、6 and 12 months were 17.9% 、32.0%、 40.0%. respectively . There were significant between these two groups for X-ray improvements after 12 months treatment （P〈0. 01）. Conclusion： levofloxacin combined with chemotherapy could be effective in the treatment of retreat tuberculosis.