三苯氧胺对乳腺癌患者子宫和卵巢的影响

The Influence of Tamoxifen on Uterus and Ovary in the Patients with Breast Cancer

目的评价服用三苯氧对乳腺癌患者子宫和卵巢的影响。方法53例乳腺癌患者术后服用三苯氧胺,每天20mg。服药前1周内及服药中每3～6个月采用超声检查子宫和卵巢。结果可评价病例49例,服药时间3～60个月,平均(26.5±2.1)月。其中绝经前乳腺癌患者27例,绝经后乳腺癌患者22例。服药前后子宫内膜厚度在绝经前组分别平均为(4.2±0.8)mm和(4.6±1.0)mm,在绝经后组分别平均为(2.6±0.3)mm和(3.2±0.5)mm,两组用药前后差异均无显著性意义。用药前后子宫内膜≥5mm的例数、有卵巢囊肿例数和有子宫肌瘤例数在绝经前组分别为5、3、2例和8、3、4例,在绝经后组分别为0、0、0例和3、0、1例。结论三苯氧胺会引起子宫内膜增厚,子宫肌瘤也有增多。对于服用三苯氧胺的乳腺癌患者应警惕子宫内膜癌的发生。

Objective：The purpose was to investigate the influence of tamoxifen on uterus and ovary. Methods：Fifty-three breast cancer patients received tamoxifen 20 mg daily . All the patients underwent a uhrasonography examination every 3～6 months. Results： Forty-nine patients were available for evaluation. The mean endometrial thickness was （ 4.2±0.8）mm and （4. 6±1.0） mm before and after tamoxifen treatment respectively（P〉0.05） in 27 premenopausal patients, and was （2.6±0.3）mm and （3.2±0.5）mm before and after respectively（P〉0.05） in 22 postmenopausal patients. Patients with endometrial thickness ≥5mm,ovarian cyst and uterine myoma were 5,3,2 and 8,3,4 before and after tamoxifen treatment respectively in the premenopausal patients, and were 0,0,0and 3,0,1 before and after respectively in the postmenopausal patients. Conclusion：Tamoxifen could increase endometrial hyperplasia and uterine myoma. We should be alert in the occurrence of endometrial cancer.