低分子量肝素与阿司匹林联合治疗不稳定型心绞痛的临床观察

Clinical observation of low- modecular- weight heparin combined with aspirin on patients with unstable angina

目的评价低分子量肝素(法安明)与阿司匹林联合治疗不稳定型心绞痛(UA)的临床疗效。方法将48例UA患者随机分为对照组(阿司匹林)及治疗组(法安明+阿司匹林),疗程为1周。结果1周后总有效率:治疗组87.5%,对照组66.7(%P<0.05);观察2周治疗组无1例发生急性心肌梗死,对照组发生2例(8.3%);治疗组未发现明显不良反应。结论在常规治疗基础上加用法安明,能更有效地控制心绞痛发作,且安全方便。

[Objective] To evaluate the clinical therapeutic efficacy of aspirin combined with Low-molecular- weight heparin （LMWH, fragmin） on the treatment of unstable angina （UA）. [Method] 48 patients with UA were randomized into a group receiving aspirin （the control group） and a group receiving aspirin plus LMWH（ the treatment group） for one week. [Result] The effective rate was 87.5% in the treatment group and 66.7% in the control group after one week （P〈0.05）; No acute myocardial infarction occurred in the treating group, two cases had acute myocardial infarction in the control group after two weeks; no obvious adverse reaction was observed in the treatment group. [Conclusion] Treatment with aspirin plus LMWH is more efficient than aspirin alone during the acute stage of UA. Treatment with LMWH is safe and convenient.