摘要
本文研究了化学氧化法合成烟酸,对电氧化法进行了探索。化学氧化法主要以高锰酸钾为氧化剂。通过正交实验,考察了各种因素对烟酸合成的影响。着重讨论了温度、氧化剂用量、反应时间和反应中水用量对反应的影响,最佳反应务件为:3-甲基吡啶:高锰酸钾(质量比)=1:2,3-甲基吡啶:水(体积比)=1:6,反应温度95～100℃,反应时间1h,该条件下的收率可达86%以上。经熔点测定和红外光谱分析可确定该产品为目标产品。
Nicotinic acid was synthesized by chemical agent oxidation as potassium and electrochemical oxidation was just refered to a little.Through the experiment, the influence of each kinds of factor to the nicotinic acid were investigated.The optimum technological onditions are determinded with orthogonal experiment, which are as follows： material molar ratio of w（3-methylpyridine）： w（ethyl alcohol） =1：2.0; v（3-methylpyridine）：v（water）=1：6, reaction temperature： 95～100℃ for 1h. Under above conditions excellent yield was odtained 86%. The product was characterized by IR and melting point analysis.
关键词
烟酸
合成
3-甲基吡啶
nicotinic acid
synthesis
3-methylpyridine
