糖调节异常285例3年后自然转归的比较

Natural Results and Comparision of 285 Cases IGR of 3 Years Later

目的探讨糖调节异常(IGR)的自然转归及比较空腹血糖受损(IFG)和葡萄糖耐量异常(IGT)之间相关因素的异同。方法对329名不愿干预治疗的IGR患者随访3年,对OGTT等检测结果进行相应分析、比较。结果单纯IFG(I-IFG)糖尿病年转化率10.35%,单纯IGT(I-IGT)糖尿病年转化率11.90%,IFG/IGT糖尿病年转化率20%,I-IFG组病人和I-IGT组相比,发病年龄较年轻,体重指数、腰围数较小,肥胖者较少,而且高血压、高胆固醇程度也较轻,有显著差异(P<0.05)。结论IGT和IFG都与发生糖尿病的危险性显著相关,而最大危险是IGT/IFG人群,I-IFG组和I-IGT组相比,其胰岛素抵抗程度比较轻。

Objective To investigate the natural results of IGR and to compare the correlation factor between IFG and IGT. Methods We choosed 329 patients without any therapy, let them take OGTT and other test again 3 years later, analysed the results. Results I-IFG annual transformation rate to DM is 10.35%, I-IGT annual transformation rate to DM is 11.9% , IFG/IGT transformatiormrate to DM is 20%. Compared with I-IGT, I-IFG patients had a younger age of onset, a smaller body mass index, smaller waist circumference, less fat, lower degree of blood pressure and cholesterol（P〈0.05）. Conclusion IGT and IFG are relative to diabetic risk, the most dangerous factor is population with IGT and IFG. I-IFG have a lower insulin resistance.