充血性心力衰竭患者血浆一氧化氮、内皮素含量变化及其意义

Changes of Plasma Nitric Oxide and Endothelin Levels in Patients with Congestive Heart Failure

目的探讨充血性心力衰竭(CHF)患者血浆一氧化氮(NO)和内皮素(ET)含量变化及其意义。方法检测68例CHF患者血浆NO和ET含量,另选30例健康体检者作为对照组。结果CHF患者血浆NO和ET水平明显高于对照组(P<0.01)。且心衰程度越重,NO和ET水平越高。NO与ET呈直线正相关(r=0.6368,P<0.001)。结论血浆NO和ET水平增高是CHF病理生理特征之一,NO和ET共同参与CHF的发生发展过程。

Objective To study the clinical significance of changes in plasma nitric oxide （ NO ） and endothelin （ET）levels in patients with congestive heart failure （CHF）. Methods Levels of NO and ET in plasma were detected in 68 patients with CHF. 30 healthy subjects served as normal control. Results The levels of NO and ET in patients were significantly higher than those in normal subjects （P 〈 0.01 ）. The elevation of NO and ET levels were significant in CHF patients, there was significant correlation between NO and ET level（r = 0. 6368, P 〈 0. 001 ）. Conclusion The elevation of plasma NO and ET levels may be one of the path-physiologic characteristics in CHF. NO and ET are both involved in the development of CHF.