紫外吸收光谱法在高通量筛选中的应用

Application of UV Absorption Spectrum to High Through-Put Screening

与传统化合物的单独合成及结构性能测定相比,高通量筛选技术具有简化并缩短发现目标化合物过程的特点.以紫外吸收光谱法为手段,利用高通量筛选技术考察了CoCe/HZSM5对甲烷还原NOx反应的催化活性.研制了专用的平行反应器,使每个反应通道的反应温度相同,气体空速相近;建立了一种高通量初级筛选催化剂库的快速方法,初步评价了不同Co/Ce比的CoCe/HZSM5催化剂样品的催化活性.结果表明,当w(Co)=2.5%及m(Co)/m(Ce)=2时,催化剂的活性最高,其活性因数达到了0.67.

The combinatorial chemistry and high through-put screening technique have received considerable attention owing to their potential application. In an effort to discover new materials with useful properties, the combinatorial chemistry has been established as one of the most important methodology, which is capable of decreasing the discovery process in hundreds and thousands times. In this paper, the development of a high through-put screening technique for heterogeneous catalysts based on the UV absorption spectrum technique, named UV absorption array, is reported. The application of the high through-put screening technique in combinatorial discovery of active catalysts for the selective catalytic reduction of NOx with CH4 is also demonstrated. According to the variation of UV light intensity, owing to the UV absorption of organic compounds, the relative quantity of the reactants or the products before and after reaction could be obtained. By using this method, the Co-Ce/HZSM-5 samples with different m （Co）/m （Ce） ratios were investigated. The catalyst with ω（Co） = 2.5 % and m （Co）/m （Ce）= 2 showed remarkable activity and its active factor R was up to 0.67. This simple and cheap multiple channel setup can also be applied for the selection of other heterogeneous catalysts by changing the UV source.