骨关节炎患者高敏C反应蛋白测定的临床意义

Clinical significance of levels of serum high sensitivity C-reactive protein in evaluating conditions of osteoarthritis

目的:了解高敏C反应蛋白(hs-CRP)对骨关节炎(OA)患者病情评估的作用。方法:用免疫增强透射比浊法检测20例活动期膝关节OA患者和23例放射学(无症状)膝OA患者的hs-CRP水平,并与20例正常人相比较。结果:有膝关节疼痛的活动期OA患者的hs-CRP水平明显高于放射学无症状OA患者(P<0.01),且两组患者的血清hs-CRP水平均高于正常对照组(分别为P<0.01及P<0.05)。20例活动期患者经治疗症状减轻后hs-CRP水平明显下降(P<0.05),但仍高于正常对照组(P<0.01)。结论:hs-CRP是评估OA活动性及监测其治疗效果的一种敏感的血清学指标。

Objective To assess the clinical significance of levels of serum high sensitivity C-reactive protein （hs-CRP） in evaluating conditions of osteoarthritis （OA） . Methods Twenty cases of osteoarthritis of knee joint at active stage, 23 cases whom without symptoms but only with X-ray abnormality （radiographical OA） and 20 healthy （as control group） persons were selected. The particle enhanced immunoturbidimetric assay for quantification of low concentration of C-creative protein （hs-CRP） of these patients was used. Results The levels of hs-CRP at active stage were higher significantly than those without symptoms but only with X-ray abnormality （P 〈 0. 01）, and the levels of hs-CRP of OA patients were higher than those of normal controls （P 〈 0.01 or P 〈 0.05） . When the symptoms of 20 cases at active stage were controlled, their levels of hs-CRP decreased significantly （P 〈 0.05）, but still higher than those of normal controls（ P 〈 0. 05）. Conclusion Hs-CRP is a sensitive serum factor in assessing the activity of OA and evaluating the effect of treatment.