翼状胬肉不同手术方法疗效分析

Observation and analysis of efficacy in defferent ptergium surgery

状胬肉的临床疗效。方法137例(167眼)翼状胬肉患者随机分为A、B、C组,A组48例行单纯性翼状胬肉切除术;B组53眼行翼状胬肉切除联合新鲜羊膜移植术;C组66眼行翼状胬肉切除联合自体角膜缘干细胞移植术。术后随访6月～60月,比较各组患者术后翼状胬肉复发情况。结果A组48眼中16眼复发,复发率33.33%;B组53眼中8眼复发,为15.09%;C组66眼中3眼笔发,复发率为4.55%;A组与B组比较(χ2=4.47,P<0.05);B组与C组比较(χ2=3.90,P<0.05)差异具有显著性。结论自体角膜缘干细胞移植可有效地降低翼状胬肉术后的复发率,是目前较理想的手术方法。

Objective To observe the therapeutic effects of corneal limbal stem cell autograft transplantation, fresh amniotic membrane transplantation and pterygium excision int he treatment of pterygium. Methods One hundreds and sixty seven eyes （137 patients） were randomly divided into three groups： simple pterygium excision （group A, 48 eyes）; excision of pterygiym with fresh amniotic membrane transplantation （group B, 53 eyes） and excision of pterygium with corneal limbal stem cell autograft transplantation （group C, 66 eyes）. All patients had been follow up for 6-60 mouths, then compared the recurrence rate. Results The recurrence rate was 33.33 % in group A, （ 16 of 48 eyes were recurred. ） ; the recurrence rate was 15.09% in group B, （8 of 53 eyes were recurred. ） ; and the recurrence rate was 4.55% in group C （3 of 66 eyes were recurred. ）. The different being significant between the A group and B group （X^2=4.47, P〈0.05） and between the B group and C group （X^2=3.90, P〈0.05）. Conclusions The pterygium recurrence rate was reduced with corneal limbal stem cells autograft transplantation. It＇s an ideal method of pterygium surgery.