摘要
目的:探讨尘螨特异性IgE和白细胞介素4(IL-4)在脱敏治疗中的作用。方法:总结180例变应性鼻炎患者脱敏治疗疗效(症状评分),测定治疗前后患者血清尘螨特异性IgE和IL-4水平。结果:血清IL-4水平在治疗前(545.7±68.5)和治疗后(222.3±72.7)差异有统计学意义(P<0.01),且与症状评分有明显的正相关。血清尘螨特异性IgE水平治疗前(17.2±2.6)kUA/L和治疗后(15.6±3.4)kUA/L差异无统计学意义。结论:在变应性鼻炎的发病中尘螨特异性IgE和IL-4发挥了重要的作用。在脱敏治疗的机制中IL-4作用明显,而特异性IgE似乎没有明显的作用。
Objective：Survey the house dust mite specific IgE and interleukin-4＇s （IL-4） role in the desensitization therapy. Method： Evaluate the effects of desensitization therapy. Determine the serum level of dl and IL-4 pre and post desensitization therapy, and then test of significance and correlative analysis were made. Result： There＇s significant difference between the levels of IL-4 pre and post therapy, and it has positive correlation with the symptom score. But there＇s no significant difference between the levels of dl pre and post therapy. Conclusion：IL- 4 plays a very important role in both of the pathogenesis of allergic rhinitis and the desensitization therapy. But specific IgE may just has the same effect in the pathogenesis.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2005年第17期772-773,共2页
Journal of Clinical Otorhinolaryngology
关键词
鼻炎
变应性
脱敏治疗
免疫性
尘螨
IGE
白细胞介素4
Allergic rhinitis
Desensitization,immunologic
House dust mites
IgE
Interleukine 4
