滋肾柔肝活血法联合免疫调节剂治疗自身免疫性肝炎临床疗效评价

Therapeutic Effect of Zishen Rougan Huoxue Fang Combined with Thymopetidum on Autoimmunity Hepatitis

目的:探讨滋肾柔肝活血法联合免疫调节剂治疗自身免疫性肝炎(AIH)的临床疗效。方法:以滋肾柔肝活血中药为主联合胸腺肽及α甘草酸二铵治疗40例AIH,治疗前及治疗3个月后,对生化指标、自身抗体、免疫球蛋白、临床症状、体征及影像学进行综合分析。结果:治疗3个月后,显效20例(50%),有效18例(45%),无效2例(5%),治疗前后肝功能对比,差异有显著性意义(P<0.05)。结论:中药联合胸腺肽及α甘草酸二铵为主治疗自身免疫性肝炎疗效显著。

Objective： To study the clinical therapeutic effect on autoimmunity hepatitis （AIH） by integrated Chinese and western mediclne.Methods： The Chinese medicine to nourish kidney, smooth liver and promote blood circulation combined with immunomodulators （Thymopetidum） and diammonium glycyrrhizinate were used to treat 40 cases of AIH. After 3 months, the biochemistric indexes such as ALT, AST, γ-GT, ALP, A/G, TBil; immune indexes （auto-antibodies） such as ANA, SMA, AMA, LKM; immune globin such as IgG, IgA, IgM, γ-globinand; clinical symptom and imaging index were analyzed synthetically. Results： The market efficacy, efficacy and inefficacy cases were respectively 20 （50%）, 18 （45%）, 2 （5 % ） . The statistical significance was distinct （P 〈 0.01 ） before and after therapy. Conclusion： The therapeutic effect of the Chinese medicine （nourish kidney, smooth liver and promote blood circulation） combined with Thymopetidum and diammonium glycyrrhizinate ov AIH is effective distinctly.