摘要
对国产酒石酸泰乐菌素采用改进ｋａｒｂｅｒ法计算ＬＤ５０值，小白鼠和鸡分别为１２２２０ｍｇ／ｋｇ，２１９０ｍｇ／ｋｇ，与国外报道小鼠＞５０００～６２００ｍｇ／ｋｇ、鸡２１２２～５４００ｍｇ／ｋｇ基本一致；由此说明该药对小鼠基本无毒，对鸡为低毒。本试验还对小鼠经２０天递增给药，蓄积系数大于５．３。提示该药可作为饲料添加剂长期服用不致引起蓄积中毒。
LD50 of Tylosin tartrate(made in China)is determined by improved Karber method in this paper.Thedata in mousc is 12220 mg/kg and 2190 mg/kg in chicken,The results are in general agrcement with the results insome literatures which are over 5000～6200 mg/kg in mousc and 2122～5400 mg/kg in chicken.Our results suggestthat Tylosin tartrate(made in China)approximately has no toxicity in mouse and low tokicity in chicken. Theaceumulation coefficient in mouse determined by dose progressive incrcasc method in twenty days is over 5.3.It can therefore be concluded that Tylosin lartrate can be used in a long period of time as a feed additive and doesn′t causeaccumulative poisoning.
出处
《畜牧与兽医》
北大核心
1996年第1期13-15,共3页
Animal Husbandry & Veterinary Medicine
关键词
兽医
泰乐菌素
急性毒性试验
蓄积毒性试验
Tylosin
Acute toxicity expriment
Accumulative toxicity expriment
