KF-Al_2O_3催化下吡喃并[2,3-d]嘧啶衍生物的一步合成

One-pot Synthesis of Pyrano[2,3-d]pyrimidine Derivatives Catalyzed by KF/Al_2O_3

以芳醛、丙二腈和4,6-二羟基嘧啶为原料,以乙醇为溶剂,在80℃以KF/Al2O3为催化剂合成了一系列的吡喃并[2,3-d]嘧啶衍生物,产物的结构通过IR,1HNMR和元素分析表征,并进一步通过X射线衍射分析确证.

A series of pyrano[2,3-d]pyrimidine derivatives have been synthesized by the reaction of aromatic aldehyde, malononitrile and 4,6-dihydroxylpyrimidine in EtOH at 80℃ catalyzed by KF/Al2O3. The structures of the products were characterized by IR, ^1H NMR spectra and elemental analysis, and further confirmed by X-ray analysis.