全血检测特异性抗结核抗体对结核病快速诊断价值的研究

Diagnostic Value of Anti-LAM-IgG in Blood for Rapid Tuberculosis Detection

目的了解全血检测特异性抗结核抗体(LAM-IgG)对结核病快速诊断的价值。方法采受试者手指血20μL用金标试剂盒直接检测LAM-IgG。结果125例涂阳肺结核抗体阳性检出率为92.0%;267例涂阴肺结核抗体阳性检出率为78.3%;94例陈旧性肺结核抗体阳性检出率为75.5%;36例肺外结核抗体阳性检出率为83.3%;315例非结核抗体阳性检出率为47.6%。本试验灵敏度为82.7%(324/392),特异度为52.4%(165/315)。结论全血快速检测抗结核抗体较血清检测更方便,灵敏度高,但特异度较低,不能作为涂阴肺结核的最终诊断,此项检查可作为涂阴肺结核的辅助诊断和结核可疑者的筛选手段以及肺外结核的诊断指标之一。

Objective To understand the diagnostic value of Anti - LAM - IgG in blood for tuberculosis detection. Methods All subjects received blood LAM - IgG test with the FDTB Diagnostic Kit for tuberculosis. Results The positive rates of anti - LAM - IgG were 92.0% ,78.3% % and 75.5% in 125 patients with positive smear pulmonary tuberculosis, 267 patients with negative smear pulmonary tuberculosis and 94 obsolete pulmonary tuberculosis respectively. The positive rates of anti - LAM - IgG was 83.3% and 47.6% in 36 extrapulmonary tuberculosis and 315 non -tuberculosis cases respectively. The sensitivity and specificity of anti LAM- IgG in blood to diagnose the tuberculosis were 82.7% and 52.4%. Conclusion The Anti LAM - IgG in blood for rapid tuberculosis detection is more convenient than that in serum sensitivi.y, and low specificity. The test cant substitute for sputum smear test. It isn＇t the final diagnosis for negative smear patients s but it is useful tool for adjuvant diagnosis of negative smear patients and screening diagnosis of suspected TB cases. It is one of the diagnosis methods for extrapulmonary tuberculosis detection.